Yu-Chun (Frank) Lin Ph.D. 林玉俊
Distinguished Professor 特聘教授
Institute of Molecular Medicine 分子醫學所
Director 生醫中心主任
Biomedical Science and Engineering Center
National Tsing Hua University 國立清華大學
Address: 101, Section 2 Kuang Fu Road, Hsinchu, Taiwan (R.O.C)
Life Science Building I, Room 613
300044 新竹市光復路二段101號清華大學生科一館613室
E-mail: ycl@life.nthu.edu.tw
Office: Life Science Building I, Room 613 生科二館613室
Tel: (03)57-42421 or 校內分機42421
Lab: Life Science Building I, Room 606 生科一館606室
Tel: (03)57-42689 or 校內分機42689
Education and Employment
2024.Aug ~ present
Director, Biomedical Science and Engineering Center, National Tsing Hua University
2024.Aug ~ present
Group director, Center for EMI Excellence, National Tsing Hua University
2024. Aug ~ present
Distinguished Professor, Institute of Molecular Medicine, National Tsing Hua University
2023.Aug ~ 2024. Jul
Professor, Institute of Molecular Medicine, National Tsing Hua University
2019.Aug ~ 2023.Jul
Associate Professor, Institute of Molecular Medicine, National Tsing Hua University
2020. Feb ~ Present
Honorary Professor, Mathematical Sciences, University of Liverpool
2015.Feb ~ 2019.Jul
Assistant Professor, Institute of Molecular Medicine, National Tsing Hua University
2011.Aug ~ 2015.Jan
Research Fellow, Department of Cell Biology, Johns Hopkins University School of Medicine
2009.Jul ~ 2011.Aug
Postdoctoral Fellow, Institute of Molecular Medicine, National Taiwan University
2008.Aug ~ 2009.Jun
Military Service
2004.Aug ~ 2008.Jul
Ph.D., Department of Life Science, Tunghai University
2003.Aug ~ 2004.Jul
Master degree student, Department of Life Science, Tunghai University
1999.Aug ~ 2003.Jul
Undergraduate Student, Department of Biology, Tunghai University
Awards
2025
-
Outstanding Research Award, College of Life Sciences and Medicine, National Tsing Hua University
(清大生醫院傑出研究獎)
2024
-
Outstanding Teaching Award, National Tsing Hua University
(清大校級傑出教學獎)
-
2024 NTHU-Novatek Distinguished Talent Chair
(113年度清華-聯詠傑出人才講座)
2023
-
2023 NTHU Talent Development Fund - Distinguished Research Award
(國立清華大學傑出人才發展基金-傑出研究獎)
-
Potential Research Grant, National Tsing Hua University
(清大潛力型研究補助)
-
Spark Grant, National Tsing Hua University
(清大火種計畫補助)
-
Outstanding Research Award, College of Life Sciences and Medicine, National Tsing Hua University
(清大生科院傑出研究獎)
-
NSTC Grant for International Outstanding Researcher
(國際年輕傑出學者計畫;國科會)
-
Salary Bonus for the Recruitment and Retention of Oustanding Faculty and Research Staff, NTHU
(清大延攬及留用特殊優秀人才獎勵補助)
2022
-
Outstanding Teaching Award, College of Life Sciences and Medicine, National Tsing Hua University
(清大生科院院傑出教學獎)
-
Potential Research Grant, NTHU
(清大潛力型研究補助)
-
Salary Bonus for the Recruitment and Retention of Oustanding Faculty and Research Staff, NTHU
(清大延攬及留用特殊優秀人才獎勵補助)
-
Monitoring the College Student Research Creativity Award
(指導大專生計畫創作獎)
2021
-
Outstanding Scholar Award, Foundation for the Advancement of Outstanding Scholarship
(年輕學者創新獎;傑出人才發展基金會)
-
Outstanding Alumni Award, National Miaoli Senior High School
(苗栗高中傑出校友)
-
Outstanding Teaching Award, National Tsing Hua University
(清大校級傑出教學獎)
-
2021 Salary Bonus for the Recruitment and Retention of Oustanding Faculty and Research Staff, NTHU
(清大延攬及留用特殊優秀人才獎勵補助)
2020
-
Outstanding teaching award, College of Life Science, NTHU
(清大生科院教學優良教師)
-
58th Ten Outstanding Persons
(第58屆十大傑出青年)
-
Outstanding publication award, College of Life Science, NTHU
(清大生科院傑出論文獎)
-
2020 Salary Bonus for the Recruitment and Retention of Oustanding Faculty and Research Staff, NTHU
(清大延攬及留用特殊優秀人才獎勵補助)
2019
-
MOST Young Scholar Fellowship
(科技部年輕學者獎)
-
MOST Columbus Project
(科技部哥倫布計畫補助)
-
2019 Salary Bonus for the Recruitment and Retention of Outstanding Faculty and Research Staff, NTHU
(清大延攬及留用特殊優秀人才獎勵補助)
2018
-
Outstanding research award for junior faculty, NTHU
(清大校級新進人員研究獎)
-
14th Young Investigator Award from Tien Te Lee Biomedical Foundation
(第14屆永信李天德青年醫藥科技獎)
-
MOST grant for Excellent Junior Research Investigators
(科技部優秀青年計畫補助)
-
2018 Salary Bonus for the Recruitment and Retention of Outstanding Faculty and Research Staff, NTHU
(清大延攬及留用特殊優秀人才獎勵補助)
-
Potential Research grant, NTHU
(清大潛力型研究補助)
-
Outstanding research award for junior faculty, College of Life Science, NTHU
(清大生科院新進人員傑出研究獎)
-
Outstanding teaching award, College of Life Science, NTHU
(清大生科院傑出教學獎)
2017
Outstanding teaching award, NTHU (清大校傑出教學獎)
2016
Cash reward for outstanding teaching, College of Life Science, NTHU (清大生科院教學績優獎勵)
2016-2019
MOST grant for the cultivation of outstanding young scholars (科技部傑出學者養成計畫補助)
2016
2016 MOST special outstanding talent award (科技部延攬特殊優秀人才補助)
2015
2015 MOST special outstanding talent award (科技部延攬特殊優秀人才補助)
2013
Travel Award for American Society of Cell Biology 50th Annual Meeting, Johns Hopkins University School of Medicine
2012-2014
Postdoctoral fellowship for research abroad, National Science Council (國科會補助博士後出國研究獎學金兩年期)
2008
The 3rd NTU-Kyoto U student Mini-Symposium on Molecular and Cell Biology, 1st prize of the poster design and presentation (Kyoto, Japan)
The 16th Symposium on Recent Advances in Cellular and Molecular Biology, Excellent Poster Award
2007
Chinese Society of Cell and Molecular Biology, Research Assistant, Graduate Student and Postdocs Traveling
2006
The Phi Tau Phi Scholastic Honor Society of the Republic of China
Membership
2024
理事, 台灣生物化學及分子生物學會
2004 ~ Present
Member, American Society for Cell Biology
2005 ~ Present
Member, The Chinese Society of Cell and Molecular Biology
2005 ~ Present
Member, The Phi Tau Phi Scholastic Honor Society of the Republic of China
2018 ~ Present
Member, TienTe Lee Biomedical Foundation
Patent
TW I720319, 林玉俊、葉秩光：超音波感應蛋白質以及利用超音波刺激細胞的方法
Invited reviewers
1. Nature Methods
2. Nature Communications
3. Communications Biology
4. Brain Stimulation
5. International Journal of Medical Sciences
6. Life Science
7. BMC Biology
8. Frontiers in Molecular Biosciences
9. Developmental Cell
10. Advanced Science
11. iScience
12. Human Molecular Genetics
13. Journal of Cell Biology
14. Biomaterials
15. 國科會醫學生化分生學門複審委員
Invited talk (2015~present)
103. Jun. 2025: Yu-Chun Lin. Revisiting Microtubules Using Chemogenetic and Optogenetic Tools. Sixth Microtubule Network. Toulouse, France 第六屆法國微管研討會. 法國 圖魯斯
102. Apr. 2025: Yu-Chun Lin. Precisely Controlling Microtubule Structure and Intracellular Trafficking in Living Cells and Behaving Animals. Fourth Symposium on Super-resolution and Advanced Fluorescence Microscopy and Istvan Abraham Memorial Workshop. Pecs, Hungary 第四屆超高解析度顯微鏡會議. 匈牙利 佩奇
101. Mar, 2025: Yu-Chun Lin. Precisely Controlling Cells for Basic Research and Potential Therapeutic Applications. National Taiwan University Hospital Hsin-Chu Branch. 新竹台大分院
100. Dec, 2024: Yu-Chun Lin. Precisely Controlling Cells for Basic Research and Potential Therapeutic Applications. Moon-Shan Biomedical Research Forum. Taipei Medical University. Taipei, Taiwan. 拇山生物醫學研究講座 (臺北醫學大學)
99. Dec, 2024: Yu-Chun Lin. Precise control of microtubule structure and intracellular trafficking in living cells and behaving animals. 17th International Symposium on Nanomedicine. Nagoya Institute of Technology. Nagoya, Japan. 第17屆國際奈米醫學會議(日本名古屋工業大學)
98. Nov, 2024: Yu-Chun Lin. Precisely Controlling Cells for Basic Research and Potential Therapeutic Applications. Department of Life Science, Tunghai University, Taichung, Taiwan. 東海生科系
97. Nov, 2024: Yu-Chun Lin. Precise control of microtubule structure and intracellular trafficking in living cells and behaving animals. 2024 International Congress of Cell Biology, Cancun, Mexico (Invited speaker). 國際細胞生物會議(墨西哥坎昆)
96. Oct, 2024: Yu-Chun Lin. Sonogenetics: using ultrasound to control cells. Institute of Photonics Technologies, NTHU, HsinChu, Taiwan 清大光電所 (Invited speaker).
95. Sep, 2024: Yu-Chun Lin. Precisely controlling cells for basic research and potential therapeutic applications. 長庚醫院頂尖研究講座系列 Chang Gung Memorial Hospital, LinKou, Taiwan (Invited speaker).
94. Jun, 2024: Yu-Chun Lin. Precise control of microtubule structure and intracellular trafficking in living cells and behaving animals. 2024 Biology Summer Camp. HsinChu, Taiwan (Invited speaker) 生物夏令營
93. Jun, 2024: Yu-Chun Lin. Precise control of microtubule structure and intracellular trafficking in living cells and behaving animals. 2024 EMBL, Heidelberg, Germany. (Invited speaker) 歐洲EMBL會議 (德國海德堡)
92. Mar, 2024: Yu-Chun Lin. Precise control of microtubule structure and intracellular trafficking. NPAS Mini-Symposium on Neurobiology. Academia Sinica, Taipei, Taiwan (Invited speaker) 中研院NPAS會議
91. Oct, 2023: Yu-Chun Lin. Precise control of microtubule structure, tubulin post-translational modifications, and intracellular trafficking. 2023 Mini-symposium of membrane remodeling and trafficking. NTU, Taipei, Taiwan (Invited speaker)
90. Oct, 2023: Yu-Chun Lin. Precisely Controlling Cells for Basic Research and Potential Therapeutic Applications. 2023 Chang Gung Medical Week. Taoyuan, Taiwan 2023 長庚醫學週-醫學研究論壇 (Invited speaker)
89. Sep, 2023: Yu-Chun Lin. New tools to study how microtubules regulate cells. The 7th Transdisciplinary Workshops of Chemistry, Life Science, and Physics. Taichung, Taiwan 第七屆化學,生科,物理跨領域交流會 (Invited speaker)
88. Aug, 2023: Yu-Chun Lin. Precisely Controlling Cells for Basic Research and Potential Therapeutic Applications. Kaohsiung Ghang Gung Memorial Hospital (Invited Speaker).
87. Jun, 2023: Yu-Chun Lin. Monitoring Acute Cellular Events through Live-Cell Imaging. Nikon Seminar. (Invited speaker)
86. Apr, 2023: Yu-Chun Lin. Precise control of cellular structures and activities by chemicals, light, and ultrasound. NTHU (Invited speaker)
85. Mar, 2023: Yu-Chun Lin, Sonogenetics: Using ultrasound to non-invasively activate neurons and ameliorate neurodegenerative diseases. Symposium of Sensory and Circadian Biology, NHRI (Invited speaker).
84. Jan, 2023: Yu-Chun Lin, Precise control of microtubule structure, tubulin post-translational modifications, and vesicular trafficking. NCKU (Invited speaker).
83. Dec, 2022: Yu-Chun Lin, 利用化學小分子、光、超音波、磁場控制細胞及可能醫療應用. NTHU HBA (國立清華大學健康政策與經營管理專班)
82. Nov, 2022: Yu-Chun Lin, 超音波遺傳學：用聲音控制細胞. Tainan First Senior high school (台南一中). Tainan.
81. Nov, 2022: Yu-Chun Lin, Precise control of microtubule disassembly in living cells. 2022 ICCB & APOCB Joint Meeting. Taipei (Invited speaker).
80. Oct, 2022: Yu-Chun Lin, How to prepare a research proposal. NTHU Life Science College (Invited speaker)
79. Sep, 2022: Yu-Chun Lin, Sonogenetics: Using ultrasound to non-invasively activate neurons and ameliorate neurodegenerative diseases. 2022 Tang Prize Ceremony (唐獎頒獎典禮)(Invited speaker).
78. Jul, 2022: Yu-Chun Lin, 合成生物學：iGEM介紹及生技應用.清大高中生科營(Invited speaker).
77. Mar, 2022: Yu-Chun Lin, Precise control of cellular architectures and activities by chemicals, light, and ultrasound. Taipei Tzu Chi Hospital (台北慈濟醫院). Online (Invited speaker).
76. Mar, 2022: Yu-Chun Lin, Precise Control of Microtubule Disassembly and Post-Translational Modifications in Living Cells. 2022 The 36th Joint Annual Conference of Biomedical Science (第36屆生醫年會). Taipei, Taiwan. (Invited speaker).
75. Mar, 2022: Yu-Chun Lin, Precise Control of Microtubule Disassembly and Post-Translational Modifications in Living Cells. Department of Biological Sciences, National University of Singapore. (新加坡大學生物科學系). Online. (Invited speaker).
74. Mar, 2022: Yu-Chun Lin, Precise Control of Microtubule Disassembly and Post-Translational Modifications in Living Cells. Institute of Molecular and Cellular Biology. National Taiwan University. (台大分生所). Taipei, Taiwan. (Invited speaker).
73. Feb, 2022: Yu-Chun Lin, Precise Control of Microtubule Disassembly and Post-Translational Modifications in Living Cells. Institute of Biomedical Sciences. Academia Sinica. (中研院生醫所). Taipei, Taiwan. (Invited speaker).
72. Dec, 2021: Yu-Chun Lin, Sonogenetics: using ultrasound to non-invasively activate neurons and ameliorate neurodegenerative diseases. The 3rd Japan-Taiwan Symposium on Psychological and Physiological Acoustics Jointly held with ASJ Auditory Research Meeting (日本-台灣研究交流-聽覺研討會). Online (Keynote speaker).
71. Nov, 2021: Yu-Chun Lin, Sonogenetics: using ultrasound to non-invasively activate neurons and ameliorate neurodegenerative diseases. National Taiwan University College of Medicine. (台大醫學院). Taipei (Invited speaker).
70. Sep, 2021: Yu-Chun Lin, Precise control of microtubule disassembly and post-translational modifications in living cells. International Center for Wound Repair and Regeneration. National Cheng Kung University, Tainan, Taiwan (Invited speaker).
69. Aug, 2021: Yu-Chun Lin, Precise control of microtubule disassembly in living cells. 2021 POSTECH-NTHU conference. (Invited speaker)
68. May, 2021: Yu-Chun Lin, Precisely controlling cellular activities by chemicals, light, and ultrasound. National Taiwan University College of Medicine. (台大醫學院). Taipei (Invited speaker).
67. May, 2021: Yu-Chun Lin, 生命科學的未來：合成生物學. 高中生科培營. National Tsing Hua University. HsinChu (Invited lecturer).
65. Mar, 2021: Yu-Chun Lin, Precisely controlling cellular activities by chemicals, light, and ultrasound. Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University (清大醫環系). HsinChu (Invited speaker)
64. Feb, 2021: Yu-Chun Lin, Precisely controlling cellular activities by chemicals, light, and ultrasound. Department of Life Science, National Taiwan University (台大生科系). Taipei (invited speaker)
63. Dec, 2020: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. Hualien Tzu Chi Hospital (花蓮慈濟醫院). Hualien (invited speaker)
62. Nov, 2020: Yu-Chun Lin, Sonogenetic modulation of cellular activities via an engineered auditory-sensing protein. GCBME & TSBME 2020, Chang Yung-Fa Foundation International Convention Center, Taipei City (Invited speaker).
61. Oct, 2020: Yu-Chun Lin, Sonogenetic modulation of cellular activities via an engineered auditory-sensing protein. 2020 The Taiwan Society for Biochemistry and Molecular Biology Autumn Camp, NanYuan Farm, Tainan City (Invited speaker).
60. Oct, 2020: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. National Institute of Cancer Research, National Health Research Institutes (Invited speaker).
59. Sep, 2020: Yu-Chun Lin, Sonogenetic modulation of cellular activities via an engineered auditory-sensing protein. TSfn 2020 Interdisciplinary Neuroscience Congress, Academia Sinica (Invited speaker).
58. Aug, 2020: Yu-Chun Lin, 年輕學者養成計畫心得分享. 2020 36th Biology Retreat. Aspire Resort, Taoyuan. (Invited speaker)
57. Aug, 2020: Yu-Chun Lin, Spatiotemporally manipulating tubulin post-translational modifications in living cells. (Invited speaker) The Centriole-Centrosome-Cilium meeting in Health and Disease. IBMS, Academia Sinica.
56. Aug, 2020: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. (Invited speaker) NPAS (Neuroscience Program of Academia Sinica) Seminar at Academia Sinica.
55. Jun, 2020: Yu-Chun Lin, Sonogenetics: Using sounds to control cells! 2020 NTHUxNTUH台清好聲音研討會 (Invited speaker).
54. Jun, 2020: Yu-Chun Lin, 利用超音波無創治療神經退化疾病. 新竹榮民之家.
53. May, 2020: Yu-Chun Lin, Sonogenetics: Using sounds to control cells! YSFxWorld 2020, Taipei, Taiwan.
52. Apr, 2020: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan (Invited speaker).
51. Mar, 2020: Yu-Chun Lin, 活細胞影像遺傳學：即時觀測及精準控制不同細胞生理活性. Taipei Tzu Chi Hospital, Taipei, Taiwan (Invited speaker).
50. Nov, 2019: Yu-Chun Lin, Using chemical biology approaches to visualize the diffusion barriers in living cells. Department of mathematical science, University of Liverpool, United Kingdom (Invited speaker).
49. Nov, 2019: Yu-Chun Lin, Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein. 2019 9th Bilateral Symposium at the University of Liverpool, United Kingdom (Invited speaker).
48. Aug, 2019: Yu-Chun Lin, 年輕學者養成計畫心得分享. 2019 35th Biology Retreat. The Great Roots Forestry Spa Resort, Sanxia (Invited speaker).
47. Aug, 2019: Yu-Chun Lin, Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein. IBC, Academia Sinica. (Invited speaker)
46. Jun, 2019: Yu-Chun Lin, Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein. 2019 Mini-Symposium for Cell membranes and Trafficking Disorders. National Taiwan University. (Invited speaker)
45. Jun, 2019: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. NTU Developmental Biology and Regenerative Medicine. National Taiwan University. (Invited speaker)
44. Jun, 2019: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. International Center for Wound Repair and Regeneration. National Cheng Kung University. (Invited speaker)
43. May, 2019: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. College of Life Science, National Tsing Hua University. (Invited speaker)
42. May, 2019: Yu-Chun Lin, Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein. 2019 Advances in Biophysics and Beyond, National Tsing Hua University. (Invited speaker)
41. Apr, 2019: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. Graduate Institute of Biochemistry, National Chung Hsing University (Invited speaker).
40. Apr, 2019: Yu-Chun Lin, 生命科學的未來：合成生物學. 高中科培營 (Invited speaker).
39. Mar, 2019: Yu-Chun Lin, Sonogenetic modulation of cellular activities via an engineered auditory sensing protein, 2019 Bilateral Biotechnology & Next Generation Medicine Symposium. IBT, VNU, Hanoi, Vietnam.
38. Mar, 2019: Yu-Chun Lin, Sonogenetic modulation of cellular activities via an engineered auditory sensing protein, Vietnam Academic Science of Technology (IBT), Vietnam.
37. Mar, 2019: Yu-Chun Lin, Sonogenetic modulation of cellular activities via an engineered auditory sensing protein, Hong Kong Baptist University, Hong Kong (Invited speaker).
36. Mar, 2019: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. Institute of Biomedical Engineering, National Tsing Hua University (Invited speaker).
35. Jan, 2019: Yu-Chun Lin, Using live-cell imaging to real-time monitor cellular activities. nMACS workshop, National Ting Hua University (Invited speaker)
34. Jan, 2019: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. Research Center for Applied Sciences, Academia Sinica (Invited speaker)
33. Nov, 2018: Yu-Chun Lin, Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein. NTHU-Liverpool U Joint Research Conference (Invited speaker)
32. Nov, 2018: Yu-Chun Lin, Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein. 2018 NHRI-NTHU Joint Research Conference (Invited speaker)
31. Nov, 2018: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. National Health Research Institutes. (Invited speaker)
30. Jun, 2018: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. National Taiwan University, School of Medicine. (Invited speaker)
29. Jun, 2018: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. Chang Gung University. (Invited Speaker)
28. Jun, 2018: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light, and ultrasound. IAM, Academia Sinica. (Invited Speaker)
27. May, 2018: Yu-Chun Lin, Spatiotemporally decoding the tubulin code in living cells. Mini-symposium on membrane trafficking and remodeling. National Taiwan University. (Invited Speaker)
26. May, 2018: Yu-Chun Lin, Sonogenetics: Identification of an ultrasound-sensing protein for neuromodulation. 23rd Biophysics conference in Taiwan. National Chung Hsing University. (Invited Speaker)
25. Nov, 2017: Yu-Chun Lin. Spatiotemporally decoding the tubulin codes in living cells. 2017 The Taiwan Society for Biochemistry and Molecular Biology Autumn Camp, I-Shou University, Kaohsiung. (Invited Speaker)
24. Aug, 2017: Yu-Chun Lin. Spatiotemporally decoding tubulin code in living cells. IBMS, Academia Sinica. (Invited Speaker)
23. Jul, 2017: Yu-Chun Lin 生命科學的未來：合成生物學 (清大生科營)
22. May, 2017: Yu-Chun Lin Sonogenetics: Manipulating cellular activities by ultrasound. I3 regular seminar at NTHU. (Invited Speaker)
21. Apr, 2017: Yu-Chun Lin, 生科院紫荊季演講
20. Jan, 2017: Yu-Chun Lin, 生命科學的未來：合成生物學 (高中教師清華營)
19. Nov, 2016: Yu-Chun Lin, Spatiotemporally manipulating cellular activities by chemicals, light or ultrasound. Microscopy: Not just imaging. NHRI (Invited Speaker)
18. Oct, 2016: Yu-Chun Lin, 生命科學的未來：合成生物學 (生科院高中生生科資優生課程)
17. Sep, 2016: Yu-Chun Lin, Spatiotemporally manipulate cellular activities by chemicals, light, and ultrasound. NTHU-OSAKA U joint conference. (Invited Speaker)
16. Sep, 2016: Yu-Chun Lin, Using ultrasound to rapidly manipulate cellular activities. The 13th Taiwan International Symposium on statistical physical and complex systems. (Invited speaker)
15. Aug, 2016: Yu-Chun Lin, Spatiotemporally decoding the tubulin codes inside primary cilia. National Cheng Kung University. (Invited Speaker)
14. May, 2016: Visualizing and manipulating molecular composition and activities in primary cilia by chemical biology approaches. National Ying Ming University. (Invited Speaker)
13. Apr, 2016: Yu-Chun Lin, 生科院紫荊季演講 Jan, 2016 生命科學的未來：合成生物學 (高中教師清華營)
12. Nov, 2015: Lin, Y.C. Rapidly rewriting the tubulin codes inside primary cilia. NTHU-NHRI joint conference. (Invited Speaker)
11. Nov, 2015: Lin, Y.C. Visualizing the manipulating molecular composition and activities in primary cilia by chemical biology approaches. IBC, Academia Sinica. (Invited Speaker)
10, Oct, 2015: Lin, Y.C. Rapidly rewriting the tubulin codes inside primary cilia. International Conference on Stem cells and Developmental biology. Academia Sinica. (Invited Speaker)
9. Sep, 2015: Lin, Y.C. Visualizing and manipulating molecular composition and activities in primary cilia by chemical biology approaches. IBMS, Academia Sinica. (Invited Speaker)
8. Aug, 2015: Lin, Y.C. Using advanced techniques to manipulate cellular composition and activities. Chang Gung University. (Invited Speaker)
7. Aug, 2015: Lin, Y.C. Visualizing and manipulating molecular composition and activities in primary cilia by chemical biology approaches. National Taiwan University. (Invited Speaker)
6. Jul, 2015: Lin, Y.C. Rapidly manipulating molecular activities in primary cilia by chemical biology approaches. Osaka University. (Invited Speaker)
5. Jul, 2015: Lin, Y.C. Rapidly rewriting the tubulin codes inside primary cilia. New Biological Frontiers Illuminated by Molecular Sensors and Actuators Meeting. (Invited Speaker)
4. Apr, 2015: Lin, Y.C. Visualizing and manipulating molecular composition and activities in primary cilia by chemical biology approaches. TungHai University. (Invited Speaker)
3. Mar, 2015: Lin, Y.C. Using Chemical approaches and optogenetics to manipulate cellular composition and activity. The meeting series in the Brain Research Center, National Tsing Hua University. (Invited Speaker)
2. Mar, 2015: Lin, Y.C. Visualizing and manipulating molecular composition and activity in primary cilia. The departmental seminar series in the college of life science, National Tsing Hua University. (Invited Speaker)
1. Feb, 2015: Lin, Y.C. Manipulating molecular composition and activities in primary cilia by chemical biology approaches. The annual retreat of the Institute of molecular medicine, National Tsing Hua University. (Invited Speaker)
About me
My research career has been dedicated to understanding and manipulating spatiotemporal signal transduction within cells, with a focus on cytoskeletal dynamics, membrane trafficking, and mechanogenetic control. This journey began with the study of lipid homeostasis and signal transduction at cellular compartments such as the Golgi and primary cilia and has since evolved into the development of pioneering technologies to precisely control intracellular processes in living cells and organisms.
Early Training and Foundational Discoveries
As a graduate student in Prof. Vie Cheng’s laboratory (Tunghai University), I investigated lipid regulation in arterial endothelial cells. I discovered that PKC-mediated upregulation of ABCA1 by HDL promotes caveolin-1 oligomerization and its subsequent exit from the Golgi, enabling cholesterol efflux—a mechanism relevant to atherosclerosis prevention (Lin et al., Histochem Cytochem, 2006; Lin et al., Cardiovasc. Res, 2007; Kuo et al., BBRC, 2011; ).
During my first postdoctoral training with Prof. Fang-Jen Lee (National Taiwan University), I focused on Golgi architecture and demonstrated that ARL4A, an atypical small GTPase, orchestrates Golgi maintenance by forming a tripartite complex with GCC185 and CLASP at the trans-Golgi network (Lin et al., J. Cell Sci., 2011). This work earned me several awards and an invitation to present at an international conference in Kyoto.
Motivated by the desire to control cellular processes with higher spatiotemporal resolution, I joined Dr. Takanari Inoue’s lab at Johns Hopkins University. There, I helped improve chemically inducible dimerization (CID) systems, establishing the first dual-CID platform to reversibly control Rac/PI3K-dependent membrane ruffling in living cells (Lin et al., Angew. Chem., Int. Ed. Engl., 2013). We further developed the “Chemically Inducible Diffusion Trap (CIDT),” which enabled visualization of size-dependent protein diffusion into primary cilia, leading to the discovery of a molecular filter at the ciliary base (Lin et al., Nat Chem Biol, 2013). These advances were recognized by invited talks at the ASCB Annual Meeting and a commissioned review article (Lin et al., Curr Opin Chem Biol, 2013).
Independent Research at National Tsing Hua University
Since joining National Tsing Hua University as an assistant professor in 2015 (and promotion to associate professor in 2019, full professor in 2023, and Distinguished professor in 2024), my lab has focused on creating next-generation tools for manipulating cellular structure and signaling with high precision. Our overarching goal is to decode and reprogram cell behavior in space and time using a broad range of external stimuli, including chemicals, light, and ultrasound. This mission is pursued through three major research directions:
1. Spatiotemporal Control of Microtubules, Tubulin Modifications, and Vesicle Trafficking
We engineered systems for rapid and subtype-specific disassembly of microtubules (MTs) using chemical or optogenetic recruitment of engineered spastin (e.g., PA-Spastin), achieving ~9.7-fold faster kinetics than conventional drugs and full reversibility. These tools enabled us to resolve long-standing questions about the requirement of MTs in organelle trafficking, fusion/fission, and cytoskeletal dynamics (Liu et al., EMBO J, 2022; Lian et al., Curr Opin Cell Biol, 2024).
We also developed RIVET—a modular platform for rapid, reversible vesicle immobilization—which has been successfully applied to diverse vesicle types and animal models, including C. elegans (Chen et al., Adv Sci, 2024). In addition, we created inducible systems to manipulate tubulin post-translational modifications (e.g., glutamylation) with spatiotemporal precision. These studies revealed critical roles of glutamylation in cilia formation, Hedgehog signaling, and centrosomal MT nucleation (Hong et al., Nat Commun, 2018; EMBO J, 2025).
2. Centrosomal Organization and Diffusion Barrier Formation
We uncovered a size-dependent diffusion barrier at the centrosome core that restricts entry of macromolecules >5.8 nm, while centriolar satellites remain permissive. Using fluorescent probes and inducible dimerization systems, we identified branched actin as the key structural component of this barrier, regulating γ-TuRC access and modulating MT nucleation in a cell-cycle-dependent manner (Cheng et al., EMBO Reports, 2022). This work highlights a novel, actin-mediated mechanism of compartmentalization in membraneless organelles.
3. Sonogenetics: Non-Invasive Modulation of Cell and Brain Function
We are at the forefront of sonogenetics, developing systems that use ultrasound (US) to remotely control gene expression and cellular activity. Early tools such as SonoCID utilized sonoporation to introduce dimerizers for intracellular signal control (Fan et al., ACS Synth Biol, 2017). We later developed mPrestinNTNS, a mutated auditory protein that converts low-frequency US into calcium signals in mammalian neurons, enabling deep-brain, transcranial neuromodulation (Nano Lett, 2020; Theranostics, 2020).
In Parkinson’s and epilepsy models, we showed that US-mediated neuronal stimulation alleviates neurodegeneration and suppresses seizure activity (Fan et al., Nano Lett, 2021; Phan et al., J Control Release, 2025).